Local drug delivery from surgical thread for area-specific anesthesia

Abstract

The application of surgical suture-thread and the systemic analgesics regimens for pain control in the postoperative surgery remain the criterion standard. However, these medications have daunting adverse effects on the body's innate pain management system. To address this issue, we have developed a local analgesic-loaded suture system which could be efficiently used for surgical repair with localized sedation effect. The drug-loaded conventional suture has modified by adhesive poly-dopamine coating with the local anesthetic lidocaine. The surface modifications have been ascertained by FE-SEM imaging. The tensile strength of suture ensures required elasticity to use in surgical skin closure. In vitro drug release and the in vivo local analgesia was achieved one day after surgery and persisted approximately for one week in 80% of treated animals. Our pre-clinical results suggest that drug-loaded surgical thread may be an effective strategy for improving the overall outcome.