Serum Vascular Endothelial Growth Factor Levels and Uterine Fibroid Volume

Abstract

Objective: To investigate the correlation of serum Vascular Endothelial Growth Factor (VEGF) levels and uterine fibroid volume. Methods: Observational analytic study was carried out on 80 patients with uterine fibroids indicated myomectomy. Each sample was examined for VEGF levels and volume of myoma tissue post myomectomy was measured by using Archimedes' law. Correlation test using the Spearman test. Results: A total of 80 samples of patients were examined for VEGF levels and uterine fibroids volume. The median VEGF is 360 pg/mL, the median uterine fibroids volume is 325 ml. The Spearman'stest shows p values (<0.01) and r (0.999). Conclusions: There is a significant correlation between VEGF levels and uterine fibroids volume. The higher the VEGF level, the greater the volume of uterine fibroids.