Fluorescein angiography of the anterior segment its value in corneal disease

Abstract

A technique of fluorescein angiography has been developed for the study of microvessels in the diseased cornea. Simple modification of the Zeiss photo slit-lamp camera allows photographs of good quality to be made at a frequency of one exposure every 2'0 to 2.5 seconds. Selected examples from some 200 patients are presented and discussed. It is concluded that the method is of value in accurately recording complete vascular patterns in the cornea, and in particular that it may be used in assessing changes in vascularity over a period of time. It has been used effectively in following the response of corneal disease to therapy. The significance of the leakage of fluorescein from microvessels is discussed, and it is pointed out that, while no simple conclusion can be drawn about this process when comparing cases, it may be of some value in following a condition in an individual case over a period of time. In the latter situation, it may reflect changes in the inflammatory activity of a disease process.