A new synthetic method for an indolizidine skeleton by C-N bond formation via a π-allylpalladium complex

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Abstract

Pd(0)-catalyzed intramolecular cyclic reaction via a π-allylpalladium complex provided an indolizidine skeleton in satisfactory high and reproducible yields by using allylic compound having an acetoxyl group as a leaving group. These results must be available for syntheses of various functional indolizidine alkaloids. © 2004 Pharmaceutical Society of Japan.

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Yamada, Y., Takahashi, W., Asada, Y., Holiuchi, J., Takeda, K., & Harigaya, Y. (2004). A new synthetic method for an indolizidine skeleton by C-N bond formation via a π-allylpalladium complex. Chemical and Pharmaceutical Bulletin, 52(9), 1082–1085. https://doi.org/10.1248/cpb.52.1082

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