Short time to first void is associated with lower whole-night sleep quality in nocturia patients

Abstract

Study Objective: To examine associations between diarybased reports of the time to first void and a commonly used measure of sleep across the entire night, the Pittsburgh Sleep Quality Index (PSQI). Design and Setting: Data from the Baseline phase of a large, multi-site, US-based, randomized clinical trial of a nocturia medication were analyzed. We examined age-adjusted associations between time to first void as reported in a 3-day diary and PSQI Global and individual subscale scores. Patients: 757 patients with nocturia completing Baseline measurements Interventions: None. Measurements and Results: Using quartile analysis, higher scores indicating poorer sleep on all PSQI scales were associated (p's ≤ 0.05) with short time to first void durations. Among individuals in the lowest quartile of time to first void (< 1.17 hours), the odds ratio (OR) of a PSQI Global score > 5 was nearly 3 times (2.96; 95% CI 1.75-5.01) that of those in the highest quartile (> 2.50 h). Shorter time to first void was associated with lower sleep quality, shorter sleep duration, poorer sleep efficiency, and greater daytime dysfunction. Conclusions: Time to first void may serve as a valuable adjunctive, self-report measure for characterizing poor sleep among populations with nocturia.