Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance

Abstract

Current antibiotics effectiveness relies on higher doses and administration frequency, which are responsible for the growth of antimicrobial resistance (AMR). AMR is one of the major threatening issues of the century with last-line antibiotics already failing. To overcome such problems associated with bacterial infections, nanoparticles combined with antibiotics emerged as a promising strategy. In this work, nanocarriers comprising of gold–silica core–shell mesoporous nanoparticles (Au@MNs) and silica mesoporous nanoparticles (MNs) were synthesized, loaded with amoxicillin (Amox) and ofloxacin and investigated regarding its antibacterial activity towards S. aureus, methicillin-resistant S. aureus (MRSA), E. coli and P. aeruginosa. Both nanocarriers showed a beneficial role in the effective delivery of amoxicillin against MRSA and the well-known β-lactam resistant P. aeruginosa. Reductions of 10-fold (Amox@MNs) and 20-fold (Amox@Au@MNs) in the amount of antibiotic to treat P. aeruginosa; and a reduction of 20-fold (Amox@MNs) towards MRSA allied to a full reversion of resistance, strongly supports the promising potential of these nanocarriers to tackle antibiotics resistance.