Cobalt-catalyzed alkenylation of thiazoles with alkynes via C-H bond functionalization

Abstract

A cobalt-Xantphos catalyst has been developed for the syn addition of (benzo)thiazoles to internal alkynes via C-H bond functionalization. The reaction affords C2-alkenylated (benzo)thiazoles with high regio- and stereoselectivities under mild conditions. © Georg Thieme Verlag Stuttgart. New York.