ATTENUATION OF HAEMODYNAMIC RESPONSES FOLLOWING ENDOTRACHEAL INTUBATION: A COMPARISON BETWEEN MAGNESIUM SULPHATE AND LIDOCAINE

Abstract

BACKGROUND AND AIM Search for ideal agent to attenuate pressor response to endotracheal intubation has been a never ending process. This study compares efficacy of magnesium sulphate with lidocaine for attenuation of haemodynamic response to endotracheal intubation in patients undergoing GA. MATERIALS AND METHOD Ninety ASA-I and II patients between 18-55 yrs. scheduled for routine surgical procedures under GA requiring endotracheal intubation were randomly allocated to three groups of thirty patients each. Group M (Magnesium sulphate group) received magnesium sulphate (30 mg/kg) diluted with 10 mL NS, group L (Lidocaine group) received lidocaine (1.5 mg/kg) diluted with 10 mL NS, group C (Control) received 10 mL of NS, intravenously over 1 min prior to intubation. HR, SBP, DBP, MAP and Sp02 were recorded at T1-5 min before administration of sample drug, T2-just before intubation, T3-1 min after intubation, T4-3 min after intubation, T5-5 min after intubation. STATISTICAL ANALYSIS USED SPSS 12 and ANOVA, Unpaired 't' test and Tukey test were used to analyse data. RESULTS Haemodynamic response to endotracheal intubation was significantly (P0.05) attenuated in magnesium sulphate group than Lidocaine group, though latter also showed attenuation. No significant adverse effects were noted with either of these drugs. CONCLUSION Magnesium sulphate can safely and effectively be advocated for blunting pressor response to endotracheal intubation.