Abstract
We conducted a phase I clinical trial of an experimental live attenuated recombinant human metapneumovirus (HMPV) vaccine (rHMPV-Pa) sequentially in adults, HMPV-seropositive children, and HMPV-seronegative children, the target population for vaccination. rHMPV-Pa was appropriately restricted in replication in adults and HMPV-seropositive children but wasoverattenuated for HMPV-seronegative children.
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CITATION STYLE
Karron, R. A., Mateo, J. S., Wanionek, K., Collins, P. L., & Buchholz, U. J. (2018). Evaluation of a live attenuated human metapneumovirus vaccine in adults and children. Journal of the Pediatric Infectious Diseases Society, 7(1), 86–89. https://doi.org/10.1093/jpids/pix006
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