Abstract
Asiatic acid (AA) is one of the triterpenoids isolated from pegagan(Centella asiatica (L.) Urb.), which has the antiinflammatory activity.The present studies were aimed to synthesize triacetyl asiatic acid(2,3,23-triacetooxy-12-ene asiatic acid) and to predict itshepatotoxicity properties. Acetylation was carried out using acetic acidanhydride and ZnCl2 as a catalyst, while the hepatotoxicity propertieswere studied using Accelrys Discovery Studio 2.5 software. The structurewas elucidated with IR, Mass and NMR spectroscopic methods. The resultsshowed that the product of synthesis was confirmed as triacetyl asiaticacid, and the yield was 31.79%. The prediction of its hepatotoxicityrevealed that triacetyl asiatic acid is less hepatotoxic than AA.
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CITATION STYLE
Musfiroh, I., Puspitasari, I., Muhtadi, A., E. Kartasasmita, R., & I. Surantaatmadja, S. (2015). Acetylation of Asiatic Acid and Its Hepatotoxicity Prediction. In Proceedings of the 3rd International Conference on Computation for Science and Technology (Vol. 5). Atlantis Press. https://doi.org/10.2991/iccst-15.2015.10
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