Synthesis, docking molecule study and antibacterial activity of N'-(4-Fluorobenzylidene)-4- hydroxybenzohydrazide and N'-(4-Fluorobenzylidene)-4-hydroxybenzohydrazide)

Abstract

Many antibacterial are already resistant, so new antibacterial is needed. Objective: The compounds of N'- (4-Fluorobenzylidene) -4-hydroxybenzohydrazide, and N' - (3- Bromobenzylidene) -4-hydroxybenzohydrazide as antibacterial generally contain azometin (HN-N = CH-) and halogen groups. Before the compounds to be synthesized was done docking molecule study, to predict its activity as antibacterial. The synthesis was carried out by microwave and identification of the results with FT-IR, MS, 1H-NMR, and 13C-NMR, docking molecule study with the Molegro Virtual Docker program, and antibacterial activity by diffusion method. The obtained compounds of N '- (4-Fluorobenzylidene) -4- hydroxybenzohydrazide, and N' - (3-Bromobenzylidene) -4-hydroxybenzohydrazide 87%, and 81% yield respectively. The results of docking molecule study obtained reranked score lower than the starting material (methyl 4-hydroxybenzoate). The compounds have antibacterial activity against Gram positive (Bacillus subtilis) and Gram negative (Escherichia coli). Conclusion: N '- (4-Fluorobenzylidene) -4-hydroxybenzohydrazide and N' - (3- Bromobenzylidene) -4-hydroxybenzohydrazide have been synthesized, characterized and exhibited promised antibacterial.