P87 and p101 subunits are distinct regulators determining class I B phosphoinositide 3-kinase (PI3K) specificity

Abstract

Background: p87 and p101 represent non-catalytic subunits of class I B PI3Kγ. Results: Expression and activity of PI3Kγ is modified differently by p87 and p101 in vitro and in living cells. Conclusion: Non-catalytic subunits of PI3Kγ represent two different regulators in the absence of Gκγ or Ras. Significance: p87 and p101 determine diversity within class IB PI3K γ and allow integration in distinct PI3Kγ signaling pathways. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.