Potential Biomarkers for Alzheimer’s Disease Screened in a Small Brazilian Population

Abstract

Alzheimer’s Disease (AD) leads neurodegenerative diseases ranking and, because of this, clinical attention focus on the identification of blood, serum and plasma’ biomarkers in AD patients, since diagnostic have not a gold standard yet. In order to improve diagnose, current study explore relation between biochemical and hematological’ parameters, which are commonly applied as lipid profile, liver enzymes, glucose and hemogram. Furthermore, different stages of AD have been evaluated through Clinical Dementia Rating (CDR) and Mini Nutritional Assessment (MNA) evaluated nutritional status, since nutritional status interferes directly in parameters reached. For this purpose, this study included 30 patients, being 18(60%) women and 12(40%) men, in different stages of AD. Our data report that malnutrition level is directly related with disease progression, as discussed in literature over the years. With regard to hematological analysis, significate difference was observed between parameters and groups, where patients in moderate stage of disease improved erythrocytes and had greater values of globular volume when compared to final stage, suggesting that AD is a possible risk factor to anemia. Biochemical data also presented significate difference, showing that disease progression, High Density Lipoprotein (HDL) values and total cholesterol are directly proportional. Take into consideration significate differences from this study and since AD means a heterogeneous disease, more studies are needed to validate in vivo essays that may be relevant to identify this disease.