Improvements in Workplace Productivity in Working Patients with Major Depressive Disorder: Results from the AtWoRC Study

Abstract

Objective:To assess changes in workplace productivity and functioning in an open-label study in working patients receiving vortioxetine (10 to 20mg/d) for major depressive disorder (MDD).Methods:Associations between items in the Work Limitations Questionnaire (WLQ), the Sheehan Disability Scale (SDS), and the Work Productivity and Activity Impairment (WPAI) questionnaire were assessed at 12 and 52 weeks by Pearson correlation coefficients.Results:Significant improvements were observed across all domains of workplace productivity and functioning after 12 and 52 weeks' vortioxetine treatment. Strong correlations were seen between improvements in WLQ mental domains and WPAI presenteeism and SDS work/school items. Presenteeism showed stronger correlations with other workplace productivity measures than absenteeism.Conclusions:Presenteeism and absenteeism impact productivity in working patients with MDD. Vortioxetine confers long-term benefits across all workplace functioning domains.