Abstract
Interferon-β (IFN-beta) is administered for treatment of multiple sclerosis (MS). We report on a woman with MS who presented with severe Raynaud's phenomenon, livedo-reticularis and digital necrosis two weeks after beginning therapy with IFN-beta. Symptoms improved after the IFN-beta was discontinued and anticoagulation associated with cyclophosphamide and corticoid were introduced. Raynaud's phenomenon is probably a side effect of IFN-beta therapy for multiple sclerosis.
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Cruz, B. A., De Queiroz, E., Nunes, S. V., Cruz Filho, A., Campos, G. B., De Carvalho Monteiro, E. L., & Crivellari, H. (2000). Severe Raynaud’s phenomenon associated with interferon-beta therapy for multiple sclerosis: Case report. Arquivos de Neuro-Psiquiatria, 58(2 B), 556–559. https://doi.org/10.1590/s0004-282x2000000300025
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