Genome sequence of Streptomyces antioxidans MUSC 164T isolated from mangrove forest

Abstract

Members of Streptomyces genus are well known to produce bioactive compounds of various structures[1-3]. Having a complicated development life cycle with the ability to form spores, Streptomyces species are ubiquitous in nature and can be found in interesting places like deep sea, hot springs and also mangrove forest[3-11]. Streptomyces antioxidans MUSC 164T was originally isolated from mangrove forest in the east coast of Peninsular Malaysia and has been deposited at two culture collec-tion centres (=DSM 101523T = MCCC 1K01590T)[12,13]. After rounds of in vitro screening using human neuronal cell line (i.e. SH-SY5Y ), the extract of MUSC 164T was found to possess significant neuroprotective effect against hydrogen peroxide[13]. Here, a high quality genome sequence of MUSC 164T is reported, while its genome potential to produce pharmaceutically important compounds is also discussed.