Relationship between the Conductivity of Human Blood and Blood Counts

Abstract

Achieving a better characterization of human blood conductivity is of high relevance for medical applications. In this study we measured the complex impedance of N = 10 human whole blood samples (from N = 10 oncology patients) at room temperature (T = 22.6 ± 0.8°C) and at body temperature (T = 36.6 ± 0.4 °C). The complex impedance was measured using the measurement setup consisting of a custom made four-electrode probe and a commercially available galvanostat. The measured complex impedance data were used to calculate the conductivity of whole blood over the 631 Hz-100 kHz frequency range. The calculated conductivity data is presented and was compared with the literature data. The data from our study is in good agreement with the data available in the literature. Additionally, full blood counts were provided for N = 8 samples and Pearson correlation coefficient was calculated between the conductivity and blood counts at different frequencies. The three blood count parameters with the highest correlation coefficient are haematocrit (Hct), haemoglobin (Hgb) and red cell count (RBC). The correlation coefficient was shown to decrease as the frequency increases and was the highest at f = 631 Hz, which is the lowest reported frequency. To our knowledge this is the first study to measure low-frequency (i.e. below 1 MHz) conductivity of whole human blood at body temperature using the four-electrode technique. The results of this study represent an important contribution to the literature, which is currently limited in this area and will help further medical device design.