FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus

Abstract

Aim: To investigate the special Fourier transform infrared spectroscopy (FT-IR) spectra in normal and cancerous tissues of esophagus. Methods: Twenty-seven pairs of normal and cancerous tissues of esophagus were studied by using FT-IR and the special spectra characteristics were analyzed in different tissues. Results: Different spectra were found in normal and cancerous tissues. The peak at 1 550/cm was weak and wide in cancerous tissues but strong and high in normal tissues. The ratio of I1 647/I1 550 was 2.0 in normal tissues and 2.36 in cancerous tissues (P<0.05). The ratio of I1 550/ I1 080 was 4.5 in normal tissues and 3.4 in cancerous tissues (P<0.01). The peak at 1453 /cm was higher than at 1 402/cm in normal tissue and lower than at 1 402/cm in cancerous tissues. Conclusion: The results indicate that FTIR may be used in clinical diagnosis.