Mycobacterium tuberculosis pncA polymorphisms that do not confer pyrazinamide resistance at a breakpoint concentration of 100 micrograms per milliliter in MGIT

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Abstract

Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention.

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Whitfield, M. G., Warren, R. M., Streicher, E. M., Sampson, S. L., Sirgel, F. A., Van Helden, P. D., … Posey, J. E. (2015). Mycobacterium tuberculosis pncA polymorphisms that do not confer pyrazinamide resistance at a breakpoint concentration of 100 micrograms per milliliter in MGIT. Journal of Clinical Microbiology, 53(11), 3633–3635. https://doi.org/10.1128/JCM.01001-15

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