Preparation of substituted benzothiazole kinase inhibitors for treatment of proliferative disorders, inflammatory disorders, nervous system disorders, and other diseases.

Abstract

The present invention is directed to substituted benzothiazole compds. of formula I (wherein R1 is H, C1-6-alkyl, C1-6-alkoxy, amino, etc.; R2 is H, aryl, heteroaryl, etc.; R3 is H or C1-4-alkyl; X is carbonyl, aminocarbonyl, oxycarbonyl or sulfonyl; and R4 is C1-4-alkyl, aryl, etc.) and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition. Example compd. II was prepd. by reacting the appropriate benzothiazole amine compd. with 2,6-difluorophenylisocyanate. II had an IC50 of 5.761 μM in a CDK2 kinase assay. [on SciFinder(R)]