Host-Pathogen Interactions in Acinetobacter baumannii Infections: Mechanisms of Immune Evasion and Potential Therapeutic Targets

Abstract

The book chapter titled "Host-Pathogen Interactions in Acinetobacter baumannii Infections: Mechanisms of Immune Evasion and Potential Therapeutic Targets" provides an in-depth exploration of the complex interplay between A. baumannii, a notorious multidrug-resistant pathogen, and the host immune system. The chapter will focus on elucidating the mechanisms employed by A. baumannii to evade and subvert the immune response, leading to persistent and challenging infections. It will highlight key aspects of the host immune system, including innate and adaptive immunity, pattern-recognition receptors, and immune cell responses, in the context of A. bauman-nii infections. Additionally, the chapter discusses the virulence factors and strategies employed by A. baumannii to establish infection, such as biofilm formation and quorum sensing. Importantly, the chapter will explore potential therapeutic targets for combat-ing A. baumannii infections, including novel antimicrobial agents, immunotherapies, and host-directed therapies. The comprehensive analysis of host-pathogen interactions and identification of therapeutic strategies presented in this chapter contribute to our understanding of A. baumannii infections and pave the way for future research directions and healthcare interventions in combating this formidable pathogen.