Cytotoxicity of 6-Mercaptopurine via Loading on PVA-Coated Magnetite Nanoparticles Delivery System: A New Era of Leukemia Therapy

Abstract

Fe 3 O 4 were synthesized via chemical co-precipitation method in which NH 4 OH acted as reducing agent to obtain water-dispersible, biocompatible, magnetite (Fe 3 O 4) nanoparticles. The latters were coated with polyvinyl alcohol (PVA) and 6-Mercaptopurine (6-MP) drug was then loaded into the surface of PVA-coating-Fe 3 O 4 nanoparticles. The structural, morphological and magnetic characterization of the uncoated, coated and 6-MP loaded iron oxide nanoparticles are presented here. The particles were characterized by XRD, HR-TEM, TGA, FTIR and vibrating sample magnetometer (VSM). Cytotoxicity of 6-Mercaptopurine loaded into PVA-coated magnetite nanoparticles as a new era of leukemia therapy was studied aiming to improve its therapeutic effects by decreasing its dose as well its side effects.