Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis

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The underlying mechanism in postmenopausal osteoporosis (PO) is an imbalance between bone resorption and formation. This study was conducted to investigate whether oxidative stress (OxS) might have a role in this derangement of bone homeostasis. In a sample of 167 postmenopausal women, we found that increased serum levels of a lipid peroxidation marker, hydroperoxides, were negatively and independently associated with decreased bone mineral density (BMD) in total body (r = - 0.192, P < 0.05), lumbar spine (r = - 0.282, P < 0.01), and total hip (r = - 0.282, P < 0.05), as well as with increased bone resorption rate (r = 0.233, P < 0.05), as assessed by the serum concentration of C-terminal telopeptide of type I collagen (CTX-1). On the contrary, the OxS marker failed to be correlated with the serum levels of bone-specific alkaline phosphatase (BAP), that is, elective marker of bone formation. Importantly, multiple regression analysis revealed that hydroperoxides is a determinant factor for the statistical association between lumbar spine BMD and CTX-1 levels. Taken together, our data suggest that OxS might mediate, by enhancing bone resorption, the uncoupling of bone turnover that underlies PO development. © 2014 Carlo Cervellati et al.




Cervellati, C., Bonaccorsi, G., Cremonini, E., Romani, A., Fila, E., Castaldini, M. C., … Massari, L. (2014). Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis. BioMed Research International, 2014. https://doi.org/10.1155/2014/569563

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