2-Bromoacetophenone

Abstract

(A) Boruah and co-workers3 reported an efficient synthesis of indolizines in excellent yields via a microwave-mediated, one-pot, three-component reaction of 2-bromoacetophenone, pyridine, and acetylene, catalyzed by basic Al2O3. (Image Presented) (B) Yadav et al. reported vic-diallylation and dipropargylation of 2- bromoacetophenone with allyl and propargyl indium reagents, generated in situ from metallic indium and allyl or propargyl bromide to produce 4-aryl-octa-1,7-dien-4-ol derivatives in good yields.4 (Image Presented) (C) Das et al.5 developed a convenient method for the rapid and high-yielding synthesis of thiazoles and amino thiazoles by treatment of 2-bromoacetophenone with thioamides or thiourea in the presence of ammonium-12- molybdophosphate (AMP) at room temperature. (Image Presented) (D) An efficient synthetic procedure for fused 2,3-dihydrofuran derivatives was developed by Chao-Guo Yan and co-workers 6 with the assistance of pyridinium ylide. A sequential one-pot, two-step tandem reaction starting from pyridine, aromatic aldehyde, dimedone or 4-hydroxy coumarin and 2-bromoacetophenone with triethyl amine as catalyst proceeded smoothly in acetonitrile. (Image Presented) (E) Anabha and co-workers7 reported the synthesis of substituted 2-ylidene-1,3-oxathioles from aroyl dithiocarboxylates and 2-bromoacetophenone in good yields. The aroyl dithiocarboxylates were prepared by treatment of active methylene ketones with trithiocarbonate in the presence of sodium hydride. (Image Presented) (F) An efficient method for the synthesis of 2,4,6-triarylpyridines has been accomplished via microwave-promoted and BF 3·OEt2-catalyzed one-pot reaction of ω-pyrrolidinoacetophenone with chalcone. ω-Pyrrolidinoacetophenone was prepared via condensation of 2-bromoacetophenone with pyrrolidine in refluxing methanol.8 (Image Presented). © 2010 Georg Thieme Verlag Stuttgart, New York.