Enhancement of insulin absorption through mucosal membranes using cationic polymers

3Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

Cationic polymers (e.g., cationated gelatins, cationated pullulans and poly-L-arginines) have potential to promote transmucosal delivery of peptide and protein drugs without producing any toxic effects on epithelial cells. These cationic polymers could interact with the mucosal membranes and increase the number of pathways for water-soluble macromolecules in the tight junctions. In the case of insulin having negative charges in neutral solutions, interaction between the cationic polymers and insulin is also important to promote suitable delivery. An appropriate interaction can help insulin to access to cell surface, but too strong interaction suppresses insulin absorption. When the absorption-enhancing effects of sperminated pullulans and gelatin having different numbers of amino groups on the pulmonary absorption of insulin in rats were evaluated, their enhancing effects correlated with the amino group content. Cationic polymers having suitable charge density will be useful for pulmonary delivery systems of insulin. © 2010 The Pharmaceutical Society of Japan.

References Powered by Scopus

Absorption Enhancers for Nasal Drug Delivery

251Citations
N/AReaders
Get full text

Screening of cationic compounds as an absorption enhancer for nasal drug delivery

98Citations
N/AReaders
Get full text

Systemic delivery of drugs to humans via inhalation

84Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Strategies to enhance drug absorption via nasal and pulmonary routes

198Citations
N/AReaders
Get full text

Translation of pulmonary protein therapy from bench to bedside: Addressing the bioavailability challenges

10Citations
N/AReaders
Get full text

Preparation and evaluation of enteric-coated chitosan derivative-based microparticles loaded with salmon calcitonin as an oral delivery system

8Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Seki, T. (2010). Enhancement of insulin absorption through mucosal membranes using cationic polymers. In Yakugaku Zasshi (Vol. 130, pp. 1115–1121). https://doi.org/10.1248/yakushi.130.1115

Readers' Seniority

Tooltip

Researcher 5

56%

PhD / Post grad / Masters / Doc 3

33%

Professor / Associate Prof. 1

11%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 3

50%

Medicine and Dentistry 1

17%

Biochemistry, Genetics and Molecular Bi... 1

17%

Computer Science 1

17%

Save time finding and organizing research with Mendeley

Sign up for free