A novel system for identification of inhibitors of rift valley fever virus replication

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Abstract

Rift Valley fever virus (RVFV) is a human and livestock pathogen endemic to sub-Saharan Africa. We have developed a T7-dependent system for the efficient production of RVFV-like particles (RVF-VLPs) based on the virulent ZH-501 strain of RVFV. The RVF-VLPs are capable of performing a single round of infection, allowing for the study of viral replication, assembly, and infectivity. We demonstrate that these RVF-VLPs are antigenically indistinguishable from authentic RVFV and respond similarly to a wide array of known and previously unknown chemical inhibitors. This system should be useful for screening for small molecule inhibitors of RVFV replication.

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Piper, M. E., & Gerrard, S. R. (2010). A novel system for identification of inhibitors of rift valley fever virus replication. Viruses, 2(3), 731–747. https://doi.org/10.3390/v2030731

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