Reaction based fluorescent probes for hydrogen sulfide

Abstract

A reaction based fluorescence turn-on strategy for hydrogen sulfide (H 2S) was developed. This strategy was based on a H 2S- specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide. © 2012 American Chemical Society.