Abstract
In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10 nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway.
Cite
CITATION STYLE
Wang, Y., Huang, X., Han, J., Zheng, W., & Ma, W. (2013). Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway. African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM / African Networks on Ethnomedicines, 10(2), 251–257. https://doi.org/10.4314/ajtcam.v10i2.9
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
