Pneumococcus with the "6E" CPS locus produces serotype 6B capsular polysaccharide

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Abstract

Genetic studies of serogroup 6 isolates of Streptococcus pneumoniae identified putative serotype 6E. Although its capsular polysaccharide structure has not been elucidated, putative serotype 6E is described in an increasing number of studies as a potentially new serotype. We show here that SPEC6B, which is widely used as a target strain for serotype 6B opsonophagocytosis assays, has the genetic features of the putative serotype 6E but produces capsular polysaccharide identical to 6B capsular polysaccharide as determined by one-dimensional (1D) and 2D nuclear magnetic resonance (NMR). Thus, putative serotype 6E is a mere genetic variant of serotype 6B. Also, SPEC6B is appropriate as a target strain for serotype 6B opsonophagocytosis assays. This example illustrates the difficulties of assigning new bacterial serotypes based on genetic findings alone.

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Burton, R. L., Geno, K. A., Saad, J. S., & Nahm, M. H. (2016). Pneumococcus with the “6E” CPS locus produces serotype 6B capsular polysaccharide. Journal of Clinical Microbiology, 54(4), 967–971. https://doi.org/10.1128/JCM.03194-15

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