Studies on peptide antibiotics, leucinostatins i. separation, physicochemical properties and biological activities of leucinostatins A and B

Abstract

Leucinostatin, a peptide antibiotic, was separated by silica gel and alumina column chromatography into two related components designated as leucinostatin A hydrochloride (C61H111-N11O13·HCl) and leucinostatin B hydrochloride (C61H109N11O13·HCl). Physicochemical as well as biological properties of the two separated components were analyzed. These properties pointed to closely resembling chemical structures. © 1983, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.