Synthesis, characterization, and antioxidant activity of some organotin(IV) 2-nitrobenzoate using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method

Abstract

Synthesis, characterization, and antioxidant activity of diphenyltin(IV) di-2-nitrobenzoate (2), dibutyltin(IV) di-2-nitrobenzoate (4), and triphenyltin(IV) 2-nitrobenzoate (6) using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method has been successfully carried out. All compounds were well characterized by some spectroscopy techniques of UV, IR, NMR and based on physical technique by microelemental analysis. The result showed that diphenyltin(IV) di-2-nitrobenzoate was the most active in the antioxidant activity test, with an IC50 value of 8.6 μg/mL compared to the other compounds in which the dibutyltin(IV) di-2-nitrobenzoate and triphenyltin(IV) 2-nitrobenzoate have IC50 values of 12.29 μg/mL and 27.28 μg/mL, respectively, which indicated that compounds 6 and 9 were categorized active antioxidant activity. However the IC50 values of these compounds were higher than the positive control, ascorbic acid with IC50 value of 0.66 μg/mL.