Abstract
A new gymnomitrane-type sesquiterpenoid, gymnomitrane-3α,5α,9β,15-tetrol (1), was isolated from the fruiting body of Ganoderma lucidum. Its structure was elucidated using spectroscopic methods. This compound significantly inhibited the growth of epidermal growth factor receptor-tyrosine kinase inhibitor EGFR-TKI-resistant human lung cancer A549 and human prostate cancer PC3 cell lines.
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Binh, P. T., Descoutures, D., Dang, N. H., Dai Nguyen, N. P., & Dat, N. T. (2015). A new cytotoxic gymnomitrane sesquiterpene from Ganoderma lucidum fruiting bodies. Natural Product Communications, 10(11), 1911–1912. https://doi.org/10.1177/1934578x1501001125
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