Synthesis, NMR, X-ray crystallography and bioactivity of some α-aminophosphonates

Abstract

The synthesis of some new α-aminophosphonates (4a-l) was accomplished by one pot reaction of equimolar quantities of 2-amino-4-chlorophenol (1), various aromatic aldehydes (2a-l) and diethylphosphite (3) in dry toluene at reflux temperature. Products 4a-l were characterized by IR, 1H, 13C, 31P NMR and in the case of 4g by X-ray crystal diffraction data. ©ARKAT USA, Inc.