Oxidatively modified protein products and lipid peroxidation products in hypertensive patients

Abstract

Oxidative stress is considered to be one of the key factors responsible for the development of this disease. It has been proven that the increased production of free radicals and reactive oxygen species, and thus the decreased antioxidant activity of the organism, can lead to the oxidative modification of biomolecules important for the organism, including proteins and lipids. The imbalance between pro and antioxidant factors may have a direct impact on the development and course of cardiovascular diseases, including arterial hypertension. This thesis presents the most important information about the oxidative stress and the etiology of arterial hypertension, characterizes various types of products of oxidative modification of proteins and lipid peroxidation, and presents the results of research confirming the significant role of oxidative stress in the development of this disease.