Abstract
A new synthesis of sumanirole that is being developed to treat Parkinson's disease is described. The basic skeleton is constructed from 8-hydroxyquinoline and elaborated to the key tricylic intermediate 14. Further elaboration affords a 1,2-amino alcohol, which is converted to an aziridine by a new process. Finally, dissolving metal reduction to open the aziridine and protecting group removal affords sumanirole.
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CITATION STYLE
Wuts, P. G. M., Gu, R. L., Northuis, J. M., Kwan, T. A., Beck, D. M., & White, M. J. (2002). Development of a practical synthesis of sumanirole. In Pure and Applied Chemistry (Vol. 74, pp. 1359–1368). Walter de Gruyter GmbH. https://doi.org/10.1351/pac200274081359
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