Time-course of effects of external beam radiation on [18F]FDG uptake in healthy tissue and bone marrow

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Abstract

The utility of PET for monitoring responses to radiation therapy have been complicated by metabolically active processes in surrounding normal tissues. We examined the time-course of [18F]FDG uptake in normal tissue & using small animal-dedicated PET during the 2 month period following external beam radiation. Four mice received 12 Gy of external beam radiation, in a single fraction to the left half of the body.. Small animal [18F]FDG-PET scans were acquired for each mouse at 0 (pre-radiation), 1, 2,3,4,5,8,12,19,24, and 38 days following irradiation. [18F]FDG activity in various tissues was compared between irradiated and non-irradiated body halves before, and at each time point after irradiation. Radiation had a significant impact on [18F]FDG uptake in previously healthy tissues, and time-course of effects differed in different types of tissues. For example, liver tissue demonstrated increased uptake, particularly over days 3-12, with the mean left to right uptake ratio increasing 52% over mean baseline values (p < 0.0001). In contrast, femoral bone marrow uptake demonstrated decreased uptake, particularly over days 2-8, with the mean left to right uptake ratio decreasing 26% below mean baseline values (p = 0.0005). Significant effects were also seen in lung and brain tissue. Radiation had diverse effects on [18F]FDG uptake in previously healthy tissues. These kinds of data may help lay groundwork for a systematically acquired database of the time-course of effects of radiation on healthy tissues, useful for animal models of cancer therapy imminently, as well as interspecies extrapolations pertinent to clinical application eventually.

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Kesner, A. L., Lau, V. K., Speiser, M., Hsueh, W. A., Agazaryan, N., DeMarco, J. J., … Silverman, D. H. S. (2008). Time-course of effects of external beam radiation on [18F]FDG uptake in healthy tissue and bone marrow. Journal of Applied Clinical Medical Physics, 9(3), 147–156. https://doi.org/10.1120/jacmp.v9i3.2747

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