Magnetic biotransport: Analysis and applications

Abstract

Magnetic particles are finding increasing use in bioapplications, especially as carrier particles to transport biomaterials such as proteins, enzymes, nucleic acids and whole cells etc. Magnetic particles can be prepared with biofunctional coatings to target and label a specific biomaterial, and they enable controlled manipulation of a labeled biomaterial using an external magnetic field. In this review, we discuss the use of magnetic nanoparticles as transport agents in various bioapplications. We provide an overview of the properties of magnetic nanoparticles and their functionalization for bioapplications. We discuss the basic physics and equations governing the transport of magnetic particles at the micro- and nanoscale. We present two different transport models: a classical Newtonian model for predicting the motion of individual particles, and a drift-diffusion model for predicting the behavior of a concentration of nanoparticles that takes into account Brownian motion. We review specific magnetic biotransport applications including bioseparation, drug delivery and magnetofection. We demonstrate the transport models via application to these processes. © 2010 by the authors.