Formulation and evaluation of ketoprofen transdermal matrix patch containing different polymer components

Abstract

Objective: The present study is to formulate and evaluate the ketoprofen transdermal matrix patch which containing different polymer components. Methods: The transdermal matrix patch of ketoprofen was formulated using four formulas using polyethylene glycol 400, polyvinylpyrrolidone K-30, and ethyl cellulose as the polymer. The transdermal matrix patch was evaluated for various physicochemical characteristics and drug contain. The interaction between the polymers and ketoprofen was characterized using Fourier-transform infrared. Results: Surfactants, cosurfactants, and oils used for the nanoemulsion formula are tween 80, ethanol, and isopropyl myristate (IPM). Formulation of ketoconazole nanoemulsion with comparison of tween 80 concentration with ethanol (smix) 4:1 and smix with oil 9:1 was found that the formulae F1, F2, F3, F4, F5, F6, and F7 are unstable and formulae F8, F9, F10, F11, and F12 are stable at the period of manufacture. The best physical stability tests from F8, F9, F10, F11, and F12 are F10. Conclusions: Optimization of ketoconazole nanoemulsion formula was obtained at tween 80 36% concentration, 9% ethanol, and IPM 5%.