Mitofusins: Ubiquitylation promotes fusion

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Abstract

Mitochondrial genes including Mfn2 are at the center of many diseases, underscoring their potential as a therapeutical target. The Chen group now identified 15-oxospiramilactone as a chemical inhibitor of the mammalian deubiquitylase USP30, acting on Mfn1 and Mfn2. © 2014 IBCB, SIBS, CAS.

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Escobar-Henriques, M. (2014). Mitofusins: Ubiquitylation promotes fusion. Cell Research, 24(4), 387–388. https://doi.org/10.1038/cr.2014.23

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