We demonstrate intensity-based optical coherence tomography (OCT) angiography using the squared difference of two sequential frames with bulk-tissue-motion (BTM) correction. This motion correction was performed by minimization of the sum of the pixel values using axial- and lateral-pixel-shifted structural OCT images. We extract the BTM-corrected image from a total of 25 calculated OCT angiographic images. Image processing was accelerated by a graphics processing unit (GPU) with many stream processors to optimize the parallel processing procedure. The GPU processing rate was faster than that of a line scan camera (46.9 kHz). Our OCT system provides the means of displaying structural OCT images and BTM-corrected OCT angiographic images in real time.
Watanabe, Y., Takahashi, Y., & Numazawa, H. (2013). Graphics processing unit accelerated intensity-based optical coherence tomography angiography using differential frames with real-time motion correction. Journal of Biomedical Optics, 19(2), 021105. https://doi.org/10.1117/1.jbo.19.2.021105