Gender and small-farmer commercialisation: The case of two farming communities in Ghana

Abstract

To assess a possible association between yellow fever (YF) vaccine (inadvertently) administered during early pregnancy and spontaneous abortion, a hospital-based case-control study was conducted in a Brazilian town (Uberlandia, Minas Gerais) after a YF vaccine campaign in April 1993 that followed an epidemic of dengue. The study included 39 women who attended a university hospital with spontaneous abortion (cases) and 74 pregnant women attending the antenatal clinic of that hospital (controls). The crude odds ratio (relative risk estimate) of this association was 2.49, which dropped to 2.29 (95% CI 0.65-8.03) when adjusted for several confounders by multiple logistic regression. Dengue and exposure to organophosphate insecticide fogging during pregnancy were not associated with spontaneous abortion. This study, although small and with low power, provides some evidence that women vaccinated with YF vaccine during early pregnancy have an increased risk of having spontaneous abortion. Based on these findings a sensible recommendation should be to avoid YF vaccination of pregnant women unless their risk of acquiring YF outweighs the risk of vaccine-related abortion.