Blood pressure predictors of stroke in rural Chinese dwellers with hypertension: A large-scale prospective cohort study

Abstract

Background: Little was known about the different predictive power of blood pressure (BP) parameters (SBP, systolic BP; mean arterial pressure, MAP; pulse pressure, PP; and diastolic BP, DBP) and stroke incidence. This study's aim was to compare power of BP parameters predict stroke events among rural dwelling Chinese individuals with hypertension. Method: A total of 5097 hypertension patients (56.2% women; mean age, 56.3 ± 11.2 years) were included in the prospective cohort study with a median follow-up of 8.4 years. Results: Until the end of the last follow-up, there were 501 onset strokes (310 ischemic, 186 hemorrhagic, and 5 unclassified strokes) among the 5097 participants. The results showed that hazard ratio (HR) (95% confidence interval, 95% CI) with an increment of 5 mmHg were 1.095 (1.070-1.121) for PP, 1.173 (1.139-1.208) for MAP, 1.109(1.089-1.130) for SBP, 1.143(1.104-1.185) for DBP. The SBP indicated the largest β coefficient in the Cox proportional hazard model for all stroke except PP or MAP, and the SBP revealed slightly higher value than MAP (β SBP = 0.435, β MAP = 0.430, P = 0.756). Conclusions: Both PP and MAP were predictive factors for stroke. The MAP showed a stronger ability to predict stroke events than PP, and slightly inferior to SBP for hypertension patients.