An efficient one-pot synthesis of polyhydroquinoline derivatives via Hantzsch condensation using a heterogeneous catalyst under solvent-free conditions

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Abstract

An efficient Hantzsch condensation of polyhydroquinoline derivatives was reported via a four-component coupling reaction of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of HClO4-SiO 2 under solvent-free conditions. Operational simplicity, use of an economically convenient catalyst, high yield, short reaction times are the key features of this protocol. © ARKAT.

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Maheswara, M., Siddaiah, V., Damu, G. L. V., & Rao, C. V. (2006). An efficient one-pot synthesis of polyhydroquinoline derivatives via Hantzsch condensation using a heterogeneous catalyst under solvent-free conditions. Arkivoc, 2006(2), 201–206. https://doi.org/10.3998/ark.5550190.0007.223

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