Seleção de extratos brutos de plantas com atividade antiobesidade

Abstract

The prevalence of obesity has been increasing at an alarming rate and only a few medications are currently available in the market. Pancreatic lipase inhibition is one of the most widely studied mechanisms for determining the efficacy of natural products as anti-obesity agents. The aim of this study was to evaluate in vitro the inhibition of nineteen aqueous and methanol extracts on pancreatic lipase. Kinetic assays were performed in four periods with the absence and the presence of the inhibitor extract. We also tested the action of these extracts after gastric fluid simulation. Cymbopogon citratus showed the highest inhibition, followed by Costus spicatus and Baccharis trimera. The extracts have the potential to act as adjuvants in the treatment of obesity.