Abstract
Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC 50 = 0.6 μM), with a selectivity index of 54.
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CITATION STYLE
Legarda-Ceballos, A. L., Olmo, E. D., López-Abán, J., Escarcena, R., Bustos, L. A., Fonseca-Berzal, C., … Muro, A. (2015). Trypanocidal Activity of Long Chain Diamines and Aminoalcohols. Molecules, 20(6), 11554–11568. https://doi.org/10.3390/molecules200611554
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