Adipose tissue accumulation of endocrine disrupting compounds: Variant of a common theme in exposome research

Abstract

Today, a wide variety of exogenous agents (xenobiotics) collectively termed endocrine disrupting compounds (EDC) includes almost 1000 synthetic chemicals. The group of EDC is highly heterogeneous and embodies chemicals used as industrial solvents and their by-products (persistent organic pollutants and dioxins), plastics (bisphenol A) and various pesticides, herbicides and industrial pollutions. The concept of endocrine disruption refers to exogenous chemicals present in the environment, including the food and drugs, that aaect human's hormonal systems. Both epidemiological and experimental evidence suggest an association between exposure to EDC and diabetes and related cardiometabolic disorders. These compounds are not just accumulate in the white adipose tissue, but also release into the blood circulation and exhibit their patho-genic eeects on various organs. The present review is focused on the factors innuenc-ing the accumulation, metabolism and release of EDC in the white adipose tissue.