Antiproliferative constituents in umbelliferae plants. IV. Constituents in the fruits of Anthriscus sylvestris HOFFM.

Abstract

The constituents in the fruit of Anthriscus sylvestris HOFFM. were investigated, and four lignans [deoxypodophyllotoxin, morelensin, (-)- deoxypodorhizone, and (-)-hinokinin], one phenylpropanoid [l-(3',4'- dimethoxyphenyl)-1ζ-hydroxy-2-propene], two phenylpropanoid esters [3',4'- dimethoxycinnamyl (z)-2-angeloyloxymethyl-2-butenoate and 3',4'- dimethoxycinnamyl (Z)-2-tigloyloxymethyl-2-butenoate], and one polyacetylenic compound (falcarindiol) were isolated. Their antiproliferative activity against MK-1, HeLa and B16F10 cell lines is reported.