Clinical value of elevated miR-142-3p in subclinical hypothyroidism during the second trimester of pregnancy

Abstract

Subclinical hypothyroidism (SCH) during pregnancy is a common endocrine disorder, and miR-142-3p has been widely reported to be involved in thyroid function and pregnancy-related diseases. This study aimed to investigate the expression of miR-142-3p in SCH patients during the second trimester of pregnancy and clarify its clinical significance. A total of 135 healthy individuals and 161 SCH patients were included in the study. The expression level of miR-142-3p was detected by RT-qPCR, and its diagnostic efficacy was evaluated by ROC curve. Pearson correlation analysis was used to explore the correlation, and multivariate logistic regression analysis was performed to determine the potential risk factors for SCH. The results showed that the expression level of miR-142-3p was significantly increased in SCH patients and had a high diagnostic value. This indicator was positively correlated with thyroid peroxidase antibody (TPOAb) and thyroid stimulating hormone (TSH) levels, and was a risk factor for SCH during pregnancy. In addition, both SCH and abnormally elevated miR-142-3p were associated with adverse pregnancy outcomes, especially depression and preterm birth. In conclusion, the increase in miR-142-3p has a high diagnostic value in differentiating SCH patients from healthy individuals, is a risk factor for SCH, and is associated with adverse pregnancy outcomes (such as depression and preterm birth).