Two new metabolites, epoxydine A and B, from Phoma sp.

Abstract

The new compounds, epoxydines A and B (1 and 2, resp.), along with the known and related metabolites, 3 - 6, were isolated from the fungal endophyte Phoma sp. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the relative configuration of 1 was confirmed by ROESY experiments. Preliminary studies indicated that compounds 2 - 5 possess good antibacterial, antifungal, and algicidal properties. Similarly, compound 1 showed antifungal and algicidal, and compound 6 antibacterial and algicidal properties. © 2010 Verlag Helvetica Chimica Acta AG.