Difluoromethyl 2-pyridyl sulfone: A versatile carbonyl gem-difluoroolefination reagent

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Abstract

This tutorial account describes a robust carbonyl gem-difluoroolefination reagent, difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H), developed by our group, recently. The guidelines for its laboratory preparation and application are presented in detail for potential users.

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Gao, B., Zhao, Y., Hu, J., & Hu, J. (2015). Difluoromethyl 2-pyridyl sulfone: A versatile carbonyl gem-difluoroolefination reagent. Organic Chemistry Frontiers, 2(2), 163–168. https://doi.org/10.1039/c4qo00291a

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